The widespread distribution of these genes and their persistence over millenniums show that the old color lines are essentially meaningless, the scientists said. The research “dispels a biological concept of race,” Dr. Tishkoff said.
Humans develop color much as other mammals do. Special cells in the skin contain pouches, called melanosomes, packed with pigment molecules. The more pigment, the darker the skin.
Skin color also varies with the kind of pigments: Melanosomes may contain mixtures of a brown-black called eumelanin and a yellow-red called pheomelanin.
To find the genes that help produce pigments, scientists began by studying people of European ancestry and found that mutations to a gene called SLC24A5 caused cells to make less pigment, leading to paler skin. Unsurprisingly, almost all Europeans have this variant.
“We knew quite a lot about why people have pale skin if they had European ancestry,” said Nicholas G. Crawford, a postdoctoral researcher at the University of Pennsylvania and a co-author of the new study. “But there was very little known about why people have dark skin.”
Since the early 2000s, Dr. Tishkoff has studied genes in Africa, discovering variants important to everything from resistance to malaria to height.
African populations vary tremendously in skin color, and Dr. Tishkoff reasoned that powerful genetic variants must be responsible.
Studying 1,570 people in Ethiopia, Tanzania and Botswana, she and her colleagues discovered a set of genetic variants that account for 29 percent of the variation in skin color. (The remaining variation seems tied to genes yet to be discovered.)
One variant, MFSD12, was particularly mysterious: No one knew what it did anywhere in the body. To investigate its function, the researchers altered the gene in reddish lab mice. Giving them the variant found in darker-skinned Africans turned the mice gray.
More Reporting on Human Origins
As it turned out, MFSD12 can affect the production of brown-black eumelanin, producing a darker skin color.
The eight gene variants that Dr. Tishkoff and her colleagues discovered in Africans turned out to be present in many populations outside the continent. By comparing the DNA of these people, the researchers were able to estimate how long ago the genes appeared.
They turned out to be immensely old. A variant for light skin — found in both Europeans and the San hunter-gatherers of Botswana — arose roughly 900,000 years ago, for example.
Even before there were Homo sapiens, then, our distant forebears had a mix of genes for light and dark skin. Some populations may have been dark-skinned and others light-skinned; or maybe they were all the same color, produced by a blend of variants.
Neanderthals split off from our own ancestors an estimated 600,000 years ago, spreading across Europe and eastern Asia. While they became extinct about 40,000 years ago, some of their DNA has survived.
These hominins inherited the same combination of variants determining skin color, Dr. Tishkoff and her colleagues also discovered. It’s possible that some populations of Neanderthals, too, were light-skinned, and others dark-skinned.
Living humans come packaged in a wide range of hues — from pale and freckly in Ireland to dark brown in southern India, Australia and New Guinea. Researchers have argued that these varying colors evolved partly in response to sunlight.
The idea is that people who live with intense ultraviolet light benefited from dark color, pigments that shielded important molecules in their skin. In places with less sunlight, people needed lighter skin, because they were able to absorb more sunlight to make vitamin D.
The new genetic evidence supports this explanation, but adds unexpected complexity. The dark-skinned people of southern India, Australia and New Guinea, for example, did not independently evolve their color simply because evolution favored it.
They inherited the ancestral dark variants Dr. Tishkoff’s team found in Africans. “They had to be introduced from an African population,” said Dr. Tishkoff.
Yet the same is true for some genes that produce light skin in Asia and Europe. They also originated in Africa and were carried from the continent by migrants.
As Africans moved into Europe and Asia, they interbred with Neanderthals on several occasions. Last week, Michael Dannemann and Janet Kelso of the Max Planck Institute for Evolutionary Anthropology in Germany reported that people in Britain still carry a number of Neanderthal variants that color skin.
Some of the newly discovered genes appeared relatively recently in our evolution.
The pale-skin variant of SLC24A5 that’s overwhelmingly common in Europe, for example, is a recent addition to the genome, arising just 29,000 years ago, according to the new study. It became widespread only in the past few thousand years.
Dr. Tishkoff and her colleagues found it frequently not just in Europe, but also in some populations of lighter-skinned Africans in East Africa and Tanzania. Studies of ancient DNA recently discovered in Africa point to an explanation.
Several thousand years ago, it seems, a migration of early Near Eastern farmers swept into East Africa. Over many generations of interbreeding, the pale variant of SLC24A5 became common in some African populations.
In all, the new study provides “a deeper appreciation of the genetic palette that has been mixed and matched through evolution,” said Nina Jablonski, an expert on skin color at Pennsylvania State University.